Potential Drug Target Database [PDTD]

Potential Drug Target Database [PDTD]

There many websites or web pages that allows a user to search for databases related to drugs databases, biological databases, bioinformatics databases and many more. One of the web page that provides such databases are the Potential Drug Target Database [PDTD]. The figure below illustrate the web page. 

Figure 1: PDTD page 

Potential Drug Target Database [PDTD] is a dual function database that relates an informatics database to a structural database of known and potential drug targets (PDTD, 2008). In context, PDTD is a complete, web-accessible database of drug targets, and focuses on those drug targets with known 3D structures. 

According to PDTD (2008), it contains 1207 entries covering 841 known and potential drug targets with structures from the Protein Data Bank (PDB). Furthermore, the drug targets in this web page is categorized into 15 and 13 types based on two criteria which are the biochemical criteria and therapeutic areas.  

On the other hand, the database also allows to search information using PDB ID, target name and category, related disease. 

Figure 2: When user browse PDTD by two criteria

Figure 3: When users search PDTD 

Example on the usage of PDTD

Under "Browse PDTD", upon clicking "Therapeutics Areas", I choose to acquire about information related to inflammation. Therefore, I clicked on inflammation as shown below and it provided me with information with 26 targets. 

Figure 4: Information listed under therapeutics areas

Figure 5: Information related to inflammation with 26 targets

With this, I was able to obtain more detailed knowledge in regards to enzyme. For instance, as shown in the figure below, 1CQE is an enzyme used for inflammation to treat diseases like Cardiovascular diseases and many more as listed below.

 Figure 6: Example of ICQE