Databases: Therapeutic Target Database (TTD)

Therapeutic Target Databases (TTD)

Therapeutic target databases is a database which provided by Bioinformatics and Drug Design Group in National University of Singapore. This database set as a platform to the easy access of information about the known therapeutic protein and nucleic acid targets to the targeted disease, pathway information and the corresponding drugs directed at each of these targets.

Figure 1 : Shows the main page of Therapeutic Target Databases(TTD)

Users able to retrieve information from the databases based on specific search by drugs and targets by disease, drugs, targets, biomarkers and drug scaffolds. The database also provides customized search, target similarity search, drug similarity search, Quantitative Structure Activity Relationship (QSAR) models, target validation, multi target agents, drug combination and nature-derived drugs.

In the column of Drug Combination search, the database provides drug-combination data such as pharmacodynamically synergistic,addictive, and antagonist combinations and pharmacokinetically potentiative and reductive combination together with their mode of actions and combination mechanisms.

This database currently contains 2,025 targets, including 364 successful, 286 clinical trial, 44 discontinued and 1,331 research targets, 17,816 drugs, including 1,540 approved, 1,423 clinical trial, 14,853 experimental drugs and 3,681 multi-target agents (14,170 small molecules and 652 antisense drugs with available structure or oligonucleotide sequence). Targets and drugs in this database cover 61 protein biochemical class and 140 drug therapeutic classes respectively

This database also provides links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class and clinical development status.